Marc Quinternet (UMS IBSLor) and several members of the IMoPA laboratory (Marie-Eve Chagot and Alexandre Kriznik) have analyzed, with the help of the equipment of the B2S core facility, the mode of interaction between the proteins ZNHIT3 and NUFIP1 from Plasmodium falciparum, the malaria parasite vector.

These two proteins, involved in key mechanisms of ribosome biology (post-transcriptional modifications and autophagy), intertwine to form a complex that is particularly stable at high temperatures.

This work, highlighted on the cover of the journal Biochemistry, provides new structural information on two proteins that may be involved in the virulence of the malaria pathogen.

Publication: Chagot ME, Boutilliat A, Kriznik A, Quinternet M. Structural Analysis of the Plasmodial Proteins ZNHIT3 and NUFIP1 Provides Insights into the Selectivity of a Conserved Interaction. Biochemistry. 2022 Mar 22. doi: 10.1021/acs.biochem.1c00792. Epub ahead of print. PMID: .

• DOI: 10.1021/acs.biochem.1c00792
• PUBMED: 35315277
• HAL: HAL-03617333