V. Marchand (NGS Core Facility, UMS2008 IBSLor) and I. Motorine (UMR7365, IMoPA) have been involved in a study conducted by Y. Bennasser (IGH, Montpellier) and are co-authors of a Nature paper (IF=41.5).

For the first time, they have discovered that RNA modifications of HIV-1 RNA are essential to avoid innate immunity. These modifications are formed by a cellular enzyme : FTSJ3 interacts with another protein TRBP to be loaded on HIV-1 RNA. With high-throughput technologies and in particular RiboMethSeq, the researchers have discovered the presence of 17 distinct 2'-O-methylations on HIV-1 RNA.

Link to Nature

Press release of CNRS

Press release of INSERM