Sophie RAHUEL-CLERMONT
Scientific Head Microcalorimetry
And Light Scattering
Research Director, CNRS
contact
UMR7365 CNRS-Université de Lorraine
Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA)
Biopôle, Campus Brabois-Santé
9 Avenue de la Forêt de Haye, BP 20199
54505 VANDOEUVRE-LES-NANCY
Biography
Education
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2010 : Research supervisor habilitation, Université Nancy
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1994 : PhD in Enzymology, Université Nancy 1
Experiences
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2017-Present : Directeur de recherche, CNRS, Université de Lorraine, UMR7365 IMoPA, Nancy, France
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1998-2017: Chargé de recherche, CNRS, Université de Lorraine, UMR7365 IMoPA, Nancy, France
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1995-1996 : Postdoc "The Insulin hexamer as an allosteric protein", University of California Riverside, États-Unis
Responsabilities
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PI in research group "Sulfur redox enzymology"
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Member of the steering committee of the Biomolecule impact of the Lorraine University of Excellence program and head of the working group on the biological function of molecules
research
Research
Topics
- Aldehyde dehydrogenases: conformational changes during catalysis
- Enzymology of redox regulation by thiol peroxydases and their cellular partners
Key
Results
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Elucidation of an original catalytic mechanism for the reduction of sulfinic acid group by Sulfiredoxin
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A scaffold protein that chaperones a cysteine-sulfenic acid in H2O2 signaling
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Conformational changes within the active site are integral to catalysis of Aldehyde dehydrogenases
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Molecular bases of NAD/NADP cofactor specificity in dehydrogenases
Publications
teachings
Teaching
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Master 2 Life Sciences, RNA Enzyme Sciences program: Techniques for studying macromolecular interactions
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Master 2 Life sciences, Research in Health and Biology program: Molecular enzymology of repair /redox regulation enzymes
Responsabilities
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Member of the Scientific board of the Biose Doctoral School
