Jean-Baptiste VINCOURT
Manager & proteomics specialist Bottom-up LC-IM-HRMS
Research Engineer, CNRS
contact
UMR7365 CNRS-Université de Lorraine
Ingénierie Moléculaire, Cellulaire et Physiopathologie (IMoPA)
Biopôle, Campus Brabois-Santé
9 Avenue de la Forêt de Haye, BP 20199
54505 VANDOEUVRE-LES-NANCY
Biography
Education
- 2022: Habilitation to direct research (HDR): Towards a better molecular characterisation of fibrillar collagens and their maturation mechanisms..
- 2002 : PhD in Cellular and Molecular Biology, Institute of Pharmacology and Structural Biology (IPBS), University of Toulouse III.
- 1999 : Master Thesis in Biochemistry and molecular biology, Microbiology and microbial genetics Laboratory (LMGM), University of Toulouse III.
Experiences
- 2010-Present : Head of the Proteomics Core Facility at FR3209 and then at UMS2008 IBSLor
- 2008-2010 : Research Engineer at CNRS, Articular Pharmacology, Physiopathology and Engineering (PPIA) Laboratory, Vandoeuvre-Lès-Nancy, France
- 2005-2008 : Post-doc, Articular Pharmacology, Physiopathology and Engineering (PPIA) Laboratory, Vandoeuvre-Lès-Nancy, France
- Sept 2004-Mai 2005 : Post-doc, mRNA localization and cell polarity Laboratory, Developmental Biology, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
- 2003-2004 : Post-doc, National Cancer Institute Experimental Immunology branch (NCI EIB), Bethesda, MD, USA.
Responsabilities
- Head of Proteomics Core Facility
- Expert in sample preparation and instrumental development
- Expert in extracellular matrix chemical modification analysis
research
Current
Research
Mechanisms of collagen maturation
Key
Results
- Diana RM, Jolivet B, Vincourt JB, Hergalant S, Francius G, Karami Y, Khakzad H, Wild R, Bourgeais M, Robert A, Wurtz A, Barreto G, Ramalanjaona N, Helle D, Onifarasoaniaina R, Front S, Lopin-Bon C, Syx D, Malfait F, Fournel-Gigleux S, Gulberti S, Bui C. B3GALT6 mutations lead to compromised connective tissue biomechanics in Ehlers-Danlos syndrome. JCI Insight. 2025 Aug 22;10(16):e179474. doi: 10.1172/jci.insight.179474. PMID: 40857410.
- Gauthier M, Pierson J, Moulin D, Mouginot M, Bourguignon V, Rhalloussi W, Vincourt JB, Dumas D, Bensoussan D, Chastagner P, Boura C, Decot V. Deciphering Natural Killer Cell Cytotoxicity Against Medulloblastoma in vitro and in vivo: Implications for Immunotherapy. Immunotargets Ther. 2024 Jun 26;13:319-333. doi: 10.2147/ITT.S458278. PMID: 38948503.
- Henrionnet C, Gillet P, Mainard D, Vincourt JB, Pinzano A. Label-free relative quantification of secreted proteins as a non-invasive method for the quality control of chondrogenesis in bioengineered substitutes for cartilage repair. J Tissue Eng Regen Med. 2018 Mar;12(3):e1757-e1766. doi: 10.1002/term.2454.
- Riffault M, Moulin D, Grossin L, Mainard D, Magdalou J, Vincourt JB. Label-free relative quantification applied to LC-MALDI acquisition for rapid analysis of chondrocyte secretion modulation. J Proteomics. 2015 Jan 30;114:263-73. doi: 10.1016/j.jprot.2014.10.026.
- Bantsimba-Malanda C, Cottet J, Netter P, Dumas D, Mainard D, Magdalou J, Vincourt JB. Chondrocalcin is internalized by chondrocytes and triggers cartilage destruction via an interleukin-1β-dependent pathway. Matrix Biol. 2013 Oct-Nov;32(7-8):443-51. doi: 10.1016/j.matbio.2013.06.002.
Publications
