This biocompatible and modular device allows fast (<15 min) and highly sensitive analyzes to work over a wide range of flow rates associated with a wide pressure range to cover the needs for HPLC and UHPLC analysis. The device is equipped with a high-pressure binary type gradient pump with a variable flow rate of 0 to 8 ml / min, a peltier effect to thermostate columns with a temperature range of 5 ° C to 80 ° C , a diode array detector (DAD) with a range of 190 nm to 800 nm, a photomultiplier fluorescence detector, and a thermostatically controlled autosampler and collector.